2'',3'',5''-Triacetyl -azacytidine
- Product Name
- 2'',3'',5''-Triacetyl -azacytidine
- CAS No.
- 10302-78-0
- Chemical Name
- 2'',3'',5''-Triacetyl -azacytidine
- Synonyms
- Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine
- CBNumber
- CB01564248
- Molecular Formula
- C14H18N4O8
- Formula Weight
- 370.31
- MOL File
- 10302-78-0.mol
2'',3'',5''-Triacetyl -azacytidine Property
- Boiling point:
- 497.3±55.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 3.06±0.20(Predicted)
- CAS DataBase Reference
- 10302-78-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 13373
- Product name
- 2',3',5'-triacetyl-5-Azacytidine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 13373
- Product name
- 2',3',5'-triacetyl-5-Azacytidine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 13373
- Product name
- 2',3',5'-triacetyl-5-Azacytidine
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 13373
- Product name
- 2',3',5'-triacetyl-5-Azacytidine
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $834
- Updated
- 2024/03/01
- Product number
- A796030
- Product name
- 5-Azacytidine2’,3’5’-O-triacetate
- Packaging
- 50mg
- Price
- $265
- Updated
- 2021/12/16
2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Usage,Production
Description
5-
Chemical Properties
White to off-white powder
Uses
5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]
in vivo
in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].
References
[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.
2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials
Raw materials
Preparation Products
2'',3'',5''-Triacetyl -azacytidine Suppliers
View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers
- Product
- 2'',3'',5''-Triacetyl -azacytidine 10302-78-0
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-29
- Product
- 2'',3'',5''-Triacetyl -azacytidine 10302-78-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26